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NDT Advance Access first published online on November 11, 2009
This version published online on November 17, 2009
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfp545
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© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


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Nephrol Dial Transplant 2009; doi:10.1093/ndt/gfp531

The first 10% of the full text of this article appears below.

Sir,

We appreciate the chance to clarify any questions regarding our report [1] in response to the letter from D’Haese and Damment. To do so, we need to explain our results more fully than the initial limitations of space in our published letter allowed.

D’Haese and Damment stated that we ‘speculate that the concentration of lanthanum (La) must be at least 10–100 µg/g wet weight, a level far higher than previously reported in the liver of lanthanum-treated patients (0.6–2.0 µg/g) [2]’. We did not mean to speculate but rather gave a very conservative estimate of this concentration range based on several factors:

(1)  D’Haese and Damment did not mention the results from Shire's animal experiments. As stated . . . [Full Text of this Article]

Jerrold L. Abraham

Department of Pathology, SUNY Upstate Medical University Syracuse NY, USA E-mail: abrahamj@upstate.edu


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