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NDT Advance Access originally published online on March 4, 2009
Nephrology Dialysis Transplantation 2009 24(6):1726-1729; doi:10.1093/ndt/gfp084
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© The Author [2009].
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org


Tolerance in renal transplantation: is mixed chimerism the missing link?

Simon Janes, Parveen Dhaliwal and Kathryn Wood

Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, Oxford OX3 9DU, UK

Correspondence and offprint requests to: Simon Janes; E-mail: simon.janes@nds.ox.ac.uk

Keywords: mixed chimerism; tolerance; transplantation

The first 150 words of the full text of this article appear below.

Three articles published in the New England Journal of Medicine at the beginning of 2008 demonstrated that the induction or development of mixed chimerism in kidney or liver transplant recipients can lead to long-term donor specific tolerance following transplantation, irrespective of whether the chimerism is sustained or not [1–3].

Chimerism occurs when foreign (donor) haematopoietic cells are present in an individual. Complete chimerism indicates that all haematopoietic cells (100%) are derived from a donor stem cell inoculum (for example, following myeloablation and transplantation of donor haematopoietic cells), whereas in mixed chimerism donor cells of multiple lineages constitute a varying part of the total haematopoietic pool. When the presence of donor cells occurs at levels below that detectable by flow cytometry (<1%), and can only be detected by more sensitive methods such as polymerase chain reaction (PCR), it is referred to as microchimerism [4].

Individuals who have . . . [Full Text of this Article]


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