NDT Advance Access originally published online on February 24, 2009
Nephrology Dialysis Transplantation 2009 24(6):1718-1724; doi:10.1093/ndt/gfp068
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Update of secondary stroke prevention
Department of Neurology and Stroke Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany
Correspondence and offprint requests to: Hans-Christoph Diener; E-mail: hans.diener@uni-due.de
Keywords: anticoagulation; antiplatelet therapy; hypertension; ischaemic stroke; TIA
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| Introduction |
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Secondary prevention aims at preventing a stroke after a transient ischaemic attack (TIA) or a recurrent stroke after a first stroke. About 80–85% of patients survive a first ischaemic stroke [1,2]. Of those, between 8 and 15% suffer a recurrent stroke in the first year. The risk of stroke recurrence is highest in the first few weeks and declines over time [3–5]. The risk of recurrence depends on concomitant vascular diseases (coronary heart disease = CHD, peripheral arterial disease = PAD) and vascular risk factors and can be estimated by risk models [6–8]. Stroke risk after a TIA is highest in the first 3 days [9]. Therefore, immediate evaluation of patients with a stroke or TIA, identification of the pathophysiology and initiation of secondary prevention are of major importance [10]. In the following sections, we will deal with the treatment
| Hypertension |
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| High cholesterol |
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| Diabetes mellitus |
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| Supplementation of vitamins |
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Hormone replacement therapy after menopause
| Antiplatelet therapy |
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Anticoagulation in cerebral ischaemia due to cardiac embolism
Cryptogenic stroke and patent foramen ovale (PFO)
Anticoagulation in cerebral ischaemia of non-cardiac origin
Carotid endarterectomy and stenting with balloon angioplasty