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NDT Advance Access originally published online on February 25, 2009
Nephrology Dialysis Transplantation 2009 24(6):1708-1711; doi:10.1093/ndt/gfp081
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Role of renal haemodynamics in the renal risks of overweight

Jan A. Krikken, Stephan J. L. Bakker and Gerjan J. Navis

Division of Nephrology, Department of Internal Medicine, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands

Correspondence and offprint requests to: Gerjan J. Navis; E-mail: g.j.navis@int.umcg.nl

Keywords: obesity; overweight; renal haemodynamics

The first 150 words of the full text of this article appear below.

The complications of weight excess will heavily burden the health care system in the near future, considering the increasing prevalence of overweight and obesity [body mass index (BMI) > 25 and BMI > 30 kg/m2, respectively]. Renal damage is an emerging complication of weight excess. Fuelled by recent data, this paper will review the role of renal haemodynamics in the renal complications of weight excess.

The increasing impact of morbid obesity as a primary cause of renal damage is supported by a large series of renal biopsies, showing an increase in the prevalence of glomerulosclerosis associated with morbid obesity from 0.2 to 2% over a period of 15 years [1]. Recent studies, moreover, highlight the impact of less extreme weight excess as a risk factor for renal damage in patients with a pre-existing renal disorder [2], after uninephrectomy [3], in renal transplant recipients . . . [Full Text of this Article]



   Impact of weight excess on renal haemodynamics
 


   Filtration fraction predicts renal function loss independent of blood pressure and proteinuria
 


   Weight excess impairs post-donation renal reserve capacity in kidney donors
 


   The early renal phenotype of weight excess: target for intervention?
 


   Conclusions
 

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