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NDT Advance Access originally published online on February 18, 2009
Nephrology Dialysis Transplantation 2009 24(6):1705-1708; doi:10.1093/ndt/gfp069
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Klotho in chronic kidney disease—What's new?

Makoto Kuro-o

Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9072, USA

Correspondence and offprint requests to: Makoto Kuro-o; E-mail: Makoto.Kuro-o@UTSouthwestern.edu

Keywords: CKD; FGF23; Klotho; phosphate; vitamin D

The first 150 words of the full text of this article appear below.



   Introduction: Klotho and FGF23
 
Klotho, named after a Greek goddess who spins the thread of life, was identified in 1997 as a gene mutated in a mouse strain that developed a premature ageing syndrome [1]. A defect in Klotho gene expression in mice results in shortened life span, growth retardation, hypogonadism, accelerated thymic involution, skin atrophy, muscle atrophy, vascular calcification, osteopaenia, pulmonary emphysema, cognition impairment [2], hearing loss [3] and motor neuron degeneration [4] among others. These ageing-like phenotypes are associated with elevated serum levels of 1,25-dihydroxyvitamin D3, phosphate and calcium [5]. The Klotho gene encodes a single-pass transmembrane protein that belongs to a family 1 glycosidase [6] and is expressed primarily in renal tubules. Function of the Klotho protein was not clear at that time.

Fibroblast growth factor-23 (FGF23) was cloned based on sequence similarity to the other members of . . . [Full Text of this Article]



   Phosphate metabolism
 


   Phosphate toxicity
 


   Klotho and FGF23 in CKD
 

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