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NDT Advance Access originally published online on February 19, 2009
Nephrology Dialysis Transplantation 2009 24(5):1394-1396; doi:10.1093/ndt/gfp053
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Blood pressure control: hydrogen sulfide, a new gasotransmitter, takes stage*

Carmine Zoccali, Concetta Catalano and Stefania Rastelli

Nephrology, Dialysis and Transplantation Unit and CNR-IBIM Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Reggio Calabria, Italy

Correspondence and offprint requests to: Carmine Zoccali, Nephrology, Hypertension & Renal Transplantation CNR-IBIM Clinical Epidemiology of Renal Diseases and Hypertension (VI piano) Ospedali Riuniti 89124 Reggio Calabria, Italy. Fax: +0039-0965-397000; E-mail: carmine.zoccali@tin.it

Keywords: H2S; endothelium; hypertension; vasorelaxation

The first 150 words of the full text of this article appear below.



   Summary
 
Hydrogen sulfide (H2S) is the most recently characterized autocrine/paracrine messenger implicated in the control of vascular tone. A series of coherent observations now document that this gas is a strong vasorelaxant and a determinant of blood pressure in experimental models. Targeted deletion of the gene encoding cystathionine-lyase (CSE). CSE, a key enzyme for H2S biosynthesis, reduces serum H2S levels and determines age-dependent hypertension in mice. Hypertension in this model does not depend on central or on renal mechanisms or on compromised nitric oxide (NO) generation and rests solely on disturbed endothelium dependent vasorelaxation. Cholinergic stimulation of endothelial cells determines a marked increase in H2S levels which can be blocked by the anti-cholinergic drug atropine. H2S has in full the pharmacological properties which are considered characteristics of endothelium relaxing factors. Global endothelium dependent relaxing activity in the CSE knockout mice is reduced by about 60% suggesting that the lack of H2S . . . [Full Text of this Article]



   H2S: basic biochemistry and experimental models
 


   Pharmacologic insights on the vasoregulatory role of H2S
 


   Potential relevance of H2S for human diseases
 

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