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NDT Advance Access originally published online on January 31, 2009
Nephrology Dialysis Transplantation 2009 24(4):1074-1077; doi:10.1093/ndt/gfp013
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


The renal WNK kinase pathway: a new link to hypertension

Ewout J. Hoorn, Nils van der Lubbe and Robert Zietse

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Correspondence and offprint requests to: Ewout J. Hoorn, Erasmus Medical Center, Department of Internal Medicine, Room D-406, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Tel: +31-10-7040704; Fax: +31-10-4366372; E-mail: ejhoorn@gmail.com

Keywords: aldosterone; epithelial sodium channel; exosomes; pseudohypoaldosteronism; sodium-chloride cotransporter

The first 150 words of the full text of this article appear below.



   The renal WNK kinase pathway: a new link to hypertension
 
The discovery of the renal WNK kinase pathway is offering new insights into sodium, potassium and blood pressure regulation in the distal nephron. It has also largely explained the pathogenesis of a genetic form of hypertension called familial hyperkalaemic hypertension (FHHt, also known as pseudohypoaldosteronism type II or Gordon's syndrome), because it is caused by mutations in WNK kinases. However, the question is: do the renal WNK kinases have clinical significance beyond this rare syndrome? Here, we review the most recent data on renal WNK kinase physiology and discuss their potentially broader roles in electrolyte transport and hypertension.



   The renal WNK kinase pathway: current status
 
As so often in science, the identification of the WNK kinases was a serendipitous finding. In 2000, Xu et al. pursued a nested polymerase chain reaction cloning strategy to identify novel members of the mitogen-activated protein/extracellular signal-regulated protein kinase family [1]. Instead, they found a new member of the serine/ . . . [Full Text of this Article]



   WNK kinases and hypertension
 
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