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NDT Advance Access originally published online on January 7, 2009
Nephrology Dialysis Transplantation 2009 24(4):1071-1073; doi:10.1093/ndt/gfn727
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Corin, atrial natriuretic peptide and hypertension

Yiqing Zhou1, Jingjing Jiang2,3, Yujie Cui2,4 and Qingyu Wu1,2

1 Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China 2 Departments of Molecular Cardiology and Nephrology, Cleveland Clinic, OH, USA 3 Shandong University, Jinan 4 Tianjin Medical University, Tianjin, China

Correspondence and offprint requests to: Qingyu Wu, Departments of Molecular Cardiology, Nephrology and Hypertension, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Tel: +216-444-4351; Fax: +216-445-0610; E-mail: wuq@ccf.org

Keywords: blood pressure; genetic variants; natriuretic peptides; protease

The first 10% of the full text of this article appears below.



   Introduction
 
Maintaining a normal blood pressure is essential for a healthy life but apparently this is not an easy task to accomplish. Nearly 30% of adults worldwide develop hypertension [1], a disease that increases the risk of stroke, myocardial infarction and renal failure. The underlying cause of hypertension is complex and may involve many factors including blood volume, vascular response, neurohormonal regulation and genetic variations. Fundamentally, however, the disease reflects the failure of the body to adequately regulate salt and body fluid balance [2,3].

Consistently, most genetic mutations or variants associated with hypertension have been found in the genes involved in salt handling such as epithelial sodium channels, sodium/potassium transporters and proteins the renin–angiotensin–aldosterone system [4,5]. Additional genetic mutations or variants are found in the genes that may regulate kidney function such as {alpha}-adducin and endothelin 2 [4,5]. To date, however, . . . [Full Text of this Article]



   Atrial natriuretic peptide in hypertension
 


   The cardiac protease corin
 


   Corin deficiency and hypertension
 


   Conclusion
 

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