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Nephrology Dialysis Transplantation 2009 24(3):717-718; doi:10.1093/ndt/gfp022
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Laboratory issues in measuring and reporting urine albumin

W. Greg Miller1 and David E. Bruns2

1 Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298-0286, USA 2 Department of Pathology, University of Virginia Medical School, Charlottesville, VA, 22908, USA

Correspondence and offprint requests to: W. Greg Miller, Department of Pathology, Virginia Commonwealth University, PO Box 980286; Richmond, VA, 23298-0286, USA. Tel: +1-804-828-0375; Fax: +1-804-828-0353; E-mail: gmiller@vcu.edu

Keywords: albumin:creatinine ratio; urine albumin

The first 10% of the full text of this article appears below.

Urine albumin is an important biomarker for kidney damage, and its measurement is recommended by clinical practice guidelines in many countries for identifying and managing patients with kidney disease. A recent publication reviewed current practices in measurement and reporting of urine albumin concentrations and made recommendations for improvement [1]. The paper reflected the work of the Laboratory Working Group of the National Kidney Disease Education Program (NKDEP, USA) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Joint Committee for Standardization of Albumin in Urine.

Historically, the concentration of albumin excreted in 24 h was used to evaluate kidney function. The difficulty of collecting 24 h urine samples has lead to the common recommendation to use an untimed urine collection and to report the ratio of the albumin concentration to the creatinine concentration. This . . . [Full Text of this Article]


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