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NDT Advance Access originally published online on May 29, 2008
Nephrology Dialysis Transplantation 2009 24(3):714-716; doi:10.1093/ndt/gfn306
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


How to estimate GFR in children

Joris R. Delanghe

Department of Clinical Chemistry, Ghent University Hospital, Gent, Belgium

Correspondence and offprint requests to: Joris R. Delanghe, Department of Clinical Chemistry, Ghent University Hospital, De Pintelaan 185 (2P8), B-9000 Gent, Belgium. Fax: +32-9-332-4985; E-mail: joris.delanghe@ugent.be

Keywords: creatinine; cystatin C; glomerular filtration rate; standardization

The first 150 words of the full text of this article appear below.



   Introduction
 
The reference method to determine glomerular filtration rate (GFR) in children is the inulin clearance. Similarly, Cr51-EDTA, iohexol and iothalamate can be used as exogenous GFR markers [1,2]. Exogenous markers are expensive and rather impractical. Creatinine is by far the most commonly used biochemical marker of renal function. The commonest principle for assaying creatinine is the Jaffe reaction [3]. Since Jaffe only observed a complexation between picric acid and creatinine in alkaline environment and never described an analytical method, variation amongst ‘Jaffe method’ recipes is broad [4]. The analytical bias of current creatinine methods (due to interference by pseudochromogens and calibration differences) is still disappointing: the compensated Jaffe method shows a small positive bias, whereas a major positive bias is observed for the dry chemistry and the uncompensated Jaffe methods [5]. Interlaboratory variation for creatinine is still unacceptably high; recent studies have . . . [Full Text of this Article]



   Restandardization of creatinine
 


   Consequences of creatinine restandardization
 


   Alternative markers
 


   Next steps
 

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