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NDT Advance Access originally published online on November 26, 2008
Nephrology Dialysis Transplantation 2009 24(2):344-347; doi:10.1093/ndt/gfn651
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Lupus nephritis and pregnancy in the 21st century

Clara J. Day1, Graham W. Lipkin1 and Caroline O. S. Savage2

1 Department of Renal Medicine, University Hospital Birmingham, NHS Foundation Trust 2 School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

Correspondence and offprint requests to: Clara J. Day, University Hospital Birmingham, NHS Foundation Trust, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK. Tel: +44-121-627-2512; Fax: +44-121-627-2527; E-mail clara.day@uhb.nhs.uk

Keywords: Pregnancy; lupus nephritis

The first 150 words of the full text of this article appear below.

The outcome for women with SLE has undoubtedly improved with a significant fall in fetal loss over the last four decades [1] from 40% in 1960–65 to 17% 2000–03. However, pregnancy in women with lupus can still be associated with significant maternal and fetal complications. In a recent US study of 16.7 million pregnancies, 13 555 occurred in lupus patients with an increased maternal mortality of more than 20-fold and odds ratio of 1.7 for Caesarean section, 2.4 for pre-term labour and 3.0 for pre-eclampsia [2].

The maternal and fetal outcomes in patients with lupus nephritis appear to be influenced by various factors. Although some studies show no increase of flare rate in pregnancy [3,4], other studies suggest that flares of extra-renal lupus are more common in pregnancy [5] but are no more severe than in the non-pregnant state [6]. The . . . [Full Text of this Article]


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