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NDT Advance Access originally published online on December 15, 2008
Nephrology Dialysis Transplantation 2009 24(2):337-338; doi:10.1093/ndt/gfn679
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


The role of hypotension in the development of acute renal failure

Jean-Louis Vincent and Diego Castanares Zapatero

Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Belgium

Correspondence and offprint requests to: Jean-Louis Vincent, Department of Intensive Care, Erasme University Hospital, 808, route de Lennik, 1070-Brussels, Belgium. Tel: +32-2-555-33-80; Fax: +32-2-555-45-55; E-mail: jlvincen@ulb.ac.be

Keywords: hypovolaemia; resuscitation; sepsis; vasopressors

The first 10% of the full text of this article appears below.



   Introduction
 
Acute renal failure in critically ill patients is common and is associated with high morbidity and mortality rates [1]. When defined as a serum creatinine of 300 µmol/l (3.5 mg/dl) or more and/or a urine output of <500 ml/day, acute renal failure was shown to affect almost 25% of patients in the ICU [2]. Using the RIFLE criteria, studies have reported that between 10 and 67% of ICU patients have acute kidney injury [3]. Moreover, by increasing the hospital length of stay [2,4,. . . [Full Text of this Article]


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