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NDT Advance Access originally published online on August 7, 2009
Nephrology Dialysis Transplantation 2009 24(11):3280-3281; doi:10.1093/ndt/gfp381
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© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Angiotensin II type 1A receptor deficiency and longevity*

Akira Nishiyama1, Taiji Matsusaka2 and Toshio Miyata3

1 Department of Pharmacology, Kagawa University Medical School, Kagawa 2 Institute of Medical Sciences, Tokai University, Kanagawa 3 Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Miyagi, Japan

Correspondence and offprint requests to: Akira Nishiyama; E-mail: akira@kms.ac.jp

Keywords: angiotensin II (AngII); AT1A receptor; longevity; mitochondria; oxidative stress

The first 10% of the full text of this article appears below.

Benigni et al. [1] showed that mice lacking the Agtr1a gene encoding AT1A, the major mouse AT1 isoform and the closest murine homologue to the single human AT1, exhibit marked prolongation of their lifespan. The longevity in AT1A receptor-deficient mice was not related to caloric intake, but was associated with decreased cardiac, vascular, renal and pancreatic injury, reduced oxidative stress in many organs and increased proximal tubular mitochondrial volume or upregulation of the prosurvival genes nicotinamide phosphoribosyltransferase (Nampt) and sirtuin 3 (Sirt3) in the kidney. In vitro experiments showed that angiotensin II (AngII) . . . [Full Text of this Article]


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