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NDT Advance Access originally published online on August 31, 2009
Nephrology Dialysis Transplantation 2009 24(11):3269-3270; doi:10.1093/ndt/gfp432
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© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


The multi-talented podocyte

Agnes B. Fogo

Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA

Correspondence and offprint requests to: Agnes B. Fogo; E-mail: agnes.fogo@vanderbilt.edu

Keywords: diabetic nephropathy; free fatty acids; insulin resistance; podocyte

The first 10% of the full text of this article appears below.

The podocyte has long been viewed as a fascinating cell. It was first appreciated for its exquisite anatomy with primary, secondary and tertiary foot processes enveloping the glomerular capillary loops in a complex meshwork. Karnovsky described the highly specialized cell junctions at the glomerular basement membrane, the slit diaphragm, further highlighting its complex and highly specialized anatomy [1]. The podocyte was recognized as a key element of the capillary wall barrier to maintain normal permeability, and podocyte abnormalities, i.e. foot process effacement, were recognized early on to be key corollaries of proteinuria. The next era of interest in the podocyte began with . . . [Full Text of this Article]


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