NDT Advance Access originally published online on July 7, 2008
Nephrology Dialysis Transplantation 2008 23(9):2746-2749; doi:10.1093/ndt/gfn349
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
SLC2A9—a fructose transporter identified as a novel uric acid transporter*
1 Department of Pharmacy Practice, Center for Pharmacogenomics 2 Department of Nephrology, College of Medicine 3 Department of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
Correspondence and offprint requests to: MyPhuong T. Le. College of Pharmacy, University of Florida, P.O. Box 100486, Gainesville, FL 32610, USA Tel: 352-273-6007; Fax: 352 273 6121; E-mail: bachlee@ufl.edu
Keywords: fructose transporter; GLUT9; SLC2A9; uric acid transporter
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Key findings |
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SLC2A9 was recently cloned and identified as a member of the SLC2A gene family of hexose facilitative transporters, where its main physiological role was assumed to be in the transport of glucose and fructose. However, new findings have unearthed a novel role for SLC2A9 (also known as GLUT9) as a modulator of uric acid levels. Specifically, after conducting genome-wide scans, Doring et al. and Vitart et al. have identified several noncoding genetic variants of SLC2A9 that were strongly associated with a decrease in serum uric acid concentrations and an increase in fractional excretion of uric acid. Accordingly, the variants were also associated with a decreased risk of gout, suggesting a protective role for the minor alleles. Interestingly, in both of the studies, gender-specific effects were more pronounced in women than in men. Doring et al. estimated the additive effect to be –0.45 mg/ dl per copy of
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