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NDT Advance Access originally published online on May 25, 2008
Nephrology Dialysis Transplantation 2008 23(9):2743-2745; doi:10.1093/ndt/gfn279
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Notch receptors: a new target in glomerular diseases*

Peter R. Mertens, Ute Raffetseder and Thomas Rauen

Division of Nephrology and Clinical Immunology, University Hospital RWTH-Aachen, Germany

Correspondence and offprint requests to: Peter R. Mertens, Division of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany. Tel: +49-241-8089756; Fax: +49-241-8082446; E-mail: Pmertens@ukaachen.de

Keywords: diabetic nephropathy; glomerulonephritis; Notch; podocyte; TGF-β

The first 10% of the full text of this article appears below.

In 1919 the geneticist Thomas Morgan was the first to describe notched wings in fruit flies and in 1985 a novel class of single trans-membrane receptors relating to this intriguing phenotype was cloned [1]. Since then, the interest in these receptors involved in cell–cell communication has spilled over into multiple clinical disciplines and has paved the way to novel insights, ranging from Alzheimer's disease [2] and CADASIL syndrome [3] to cancer [4]. Specific inhibitors that selectively target the activation of the Notch-signalling pathway are now available and enter the stage of clinical trials. These components bear also great potential for the treatment of renal diseases, given that experimental data . . . [Full Text of this Article]



   Summary of key findings
 


   Background
 


   Take-home messages
 

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