NDT Advance Access originally published online on March 14, 2008
Nephrology Dialysis Transplantation 2008 23(6):1801-1805; doi:10.1093/ndt/gfn089
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Residual renal function: the delicate balance betweenbenefits and risks
1 Nephrology, Dialysis and Intensive Care Unit, Aider Lapeyronie University Hospital, Montpellier, France 2 Institut de Recherche et Formation en Dialyse, IRFD, Aider Lapeyronie University Hospital, Montpellier, France 3 Association pour lInstallation à Domicile des Epurations Rénales, Aider Lapeyronie University Hospital, Montpellier, France
Correspondence and offprint requests to: Bernard Canaud, Nephrology, Lapeyronie University Hospital, 371, Avenue du Doyen G. Giraud, 34295 Montpellier, France. Tel: +334-67-33-84-95; Fax: +334-67-60-37-83; E-mail: b-canaud@chu-montpellier.fr
Keywords: chronic kidney disease; dialysis adequacy; fluid volume overload; haemodialysis; peritoneal dialysis
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| Introduction |
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Residual renal function (RRF) facilitates the achievement of dialysis adequacy in stage 5 chronic kidney disease (CKD-5) patients [1]. It facilitates patients acceptance of renal replacement therapy (RRT) in minimizing dietary and fluid restriction. RRF has been confirmed recently to be a significant determinant of morbidity and mortality in dialysis patients [2]. In addition, the preservation of RRF is also highly suitable in CKD-5 patients to enhance removal or degradation of middle and large uraemic toxins implicated in long-term complications of CKD patients. Preserving RRF in incident CKD-5 patients is an old holistic dream that still remains to date a source of debate among the nephrologists [3].
The aim of this editorial is to analyse benefits and risks of maintaining RRF in dialysis patients. In this scope we explore four aspects: What are the positive effects of maintaining RRF in dialysis patients? What are
What are the positive effects of maintaining RRF in dialysis patients?
What are the negative effects of maintaining RRF in dialysis patients?
What are the factors implicated in the loss of RRF in dialysis patients?
What is the meaning of RRF persistence in dialysis patients?
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