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NDT Advance Access originally published online on February 27, 2008
Nephrology Dialysis Transplantation 2008 23(5):1481-1483; doi:10.1093/ndt/gfn059
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.For Permissions, please email: journals.permissions@oxfordjournals.org


All high-flux membranes are equal but some high-flux membranes are less equal than others

Raymond Vanholder1 and Luciano A. Pedrini2

1 Nephrology Section, Department of Internal Medicine, University Hospital, Gent, Belgium 2 Nephrology and Dialysis Division, Bolognini Hospital, Seriate, Italy

Correspondence and offprint requests to: Raymond Vanholder, Nephrology Section, Department of Internal Medicine, University Hospital, De Pintelaan, 185, B9000, Gent, Belgium. Tel: +3-2-933-24525; Fax: +3-2-933-24599; E-mail: Raymond.vanholder@ugent.be

Keywords: high-flux membranes; adequacy of dialysis; uraemic toxins; middle molecules

The first 10% of the full text of this article appears below.

The progression of renal failure is characterized by the accumulation of a host of compounds [1], which, under normal conditions, are excreted or metabolized by the healthy kidneys. Many of these compounds affect several organ systems, resulting in the uraemic syndrome.

Once this retention has progressed to disabling or life-threatening complications, quality of life and survival can only be maintained by removing retention products by dialysis or transplantation. Over time, it became clear that many of the disabling retention solutes (toxins) are difficult to remove by standard dialysis, as they are either protein bound and/or characterized by a high molecular weight (middle molecules) [2,3].

Removal of such compounds by currently available dialysis strategies can be achieved by increasing dialyzer pore size, i.e. applying high-flux membranes, alone or in combination with convection. Mainly based on secondary analyses of . . . [Full Text of this Article]


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