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NDT Advance Access originally published online on February 13, 2008
Nephrology Dialysis Transplantation 2008 23(4):1095-1097; doi:10.1093/ndt/gfm940
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome

Hassane Izzedine

Department of Nephrology, La Pitié-Salpêtriere Hospital, Paris, France

Hassane Izzedine, Service de Néphrologie, La Pitié-Salpêtrière, 47-80 Boulevard de l’Hôpital, F-75013 Paris, France. E-mail: hassan.izzedine@psl.aphp.fr

Keywords: TINU syndrome; differential diagnosis TINU syndrome; pathogenesis TINU syndrome

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In this issue of NDT, Sartelet et al. [1] provide an interesting study on Tubulointerstitial Nephritis and Uveitis syndrome (TINU), an oculorenal syndrome the pathophysiology of which is still poorly understood.

TINU is a rare disease, first described in 1975 by Dobrin [2] in two adolescent girls, in whom non-caseating granulomas were found in the bone marrow and in the lymph nodes, in association with anterior uveitis and tubulointerstitial nephritis. Since then, more than 200 cases have been reported in the ophthalmologic and paediatric literature, . . . [Full Text of this Article]


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