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NDT Advance Access originally published online on December 8, 2007
Nephrology Dialysis Transplantation 2008 23(3):800-807; doi:10.1093/ndt/gfm851
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Vaccination and chronic kidney disease

Nicolas Janus, Launay-Vincent Vacher, Svetlana Karie, Elena Ledneva and Gilbert Deray

Department of Nephrology, Pitie-Salpetriere Hospital, Paris, France

Nicolas Janus, ICAR, Department of Nephrology, Pitie-Salpetriere Hospital, 47–83, Boulevard de l’Hôpital, 75013 Paris, France. Tel: +33-1-42-17-72-30; Fax: +33-1-42-17-72-12; E-mail: nicolas.janus@psl.aphp.fr

Keywords: chronic kidney disease; vaccination

The first 150 words of the full text of this article appear below.



   Introduction
 
Infectious diseases are the second most common cause of death in end-stage renal disease (ESRD) patients [1]. Patients with chronic kidney disease (CKD) are immunocompromised and haemodialysis (HD) patients are at high risk for several infections, due to exposure to blood products [2]. CKD patients present impaired cell-mediated and humoral immunity, reducing activities of the immune system cells (B-cell, T-cell, monocytes, macrophages,...) leading to a lower seroconversion rate, a lower peak of antibody titers and a quicker decline of antibody levels in these patients as compared with healthy subjects [2]. Usual schedules of vaccination may thus be ineffective. The aim of this paper is to review the studies on the use of vaccines in ESRD patients, in order to determine whether dosage adjustment is necessary in these patients.

Hepatitis B virus (HBV) vaccination
Hepatitis B is one of the most serious infectious diseases in the world. It is estimated . . . [Full Text of this Article]

Hepatitis A virus (HAV) vaccination
Varicella vaccination
Influenza vaccination
Haemophilus influenza type B conjugate vaccine
Measles, mumps and rubella vaccine
Poliovirus vaccine
Staphylococcus aureus vaccination
Diphtheria and tetanus vaccination (tetanus and diphtheria toxoids)
Pneumococcal vaccination
Vaccination in ESRD patients infected with HIV
Vaccination of asplenic ESRD patients
In conclusion, it is impossible to make specific recommendation for asplenic ESRD patients. These patients should therefore be vaccinated as soon as possible prior to the splenectomy.Adjuvant therapy to vaccination
Vaccination and dialysis technique
Non-dialysis patients
Renal transplant patients
Contraindicated vaccines


   Conclusion
 

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Meningococcal vaccination and chronic kidney disease
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[Full Text] [PDF]