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The renal and cardiac effects of anti-hypertensive treatment of an ACE inhibitor (ramipril) vs a β-blocker (metoprolol) were explored in patients with ADPKD.
In this study population of hypertensive ADPKD patients, no differences in renal function, urinary albumin excretion or left ventricular mass index were detected between those treated with ramipril or metoprolol, respectively, during a 3-year follow-up.
This study was further discussed in an invited commentary that summarized the results of other studies and previewed the HALT PKD study, currently running in the USA.
(See editorial comment by Steinman, pages 431–433
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