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NDT Advance Access originally published online on October 31, 2007
Nephrology Dialysis Transplantation 2008 23(2):459-461; doi:10.1093/ndt/gfm702
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Klotho and Na+,K+-ATPase activity: solving the calcium metabolism dilemma?*

M. Shawkat Razzaque

Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA

Correspondence and offprint requests to: M. Shawkat Razzaque, Department of Developmental Biology, Harvard School of Dental Medicine, Research and Education Building, Room # 304, 190 Longwood Avenue, Boston, MA 02115, USA. Tel: +1-617-432-5768; Fax: +1-617-432-5767; E-mail: razzaquems@yahoo.com; mrazzaque@hms.harvard.edu

Keywords: Calcium; klotho; Na/K-ATPase; PTH

The first 150 words of the full text of this article appear below.



   Na+,K+-ATPase
 
Despite the widely known fact that low concentrations of extracellular free calcium can induce parathyroid hormone (PTH) secretion, the molecular mechanisms of such regulation and eventual calcium metabolism are not yet completely understood. The traditional view of calcium homeostasis is believed to be maintained by sensing changes in extracellular calcium in several distinct cell types, to stimulate the secretion of PTH, vitamin D and calcitonin, depending on the requirement of the body. These calciotropic hormones then act on the calcium-translocating cells of the kidney, bone and intestine to restore calcium balance [1]. New insights into calcium homeostasis were gained from a recent study by Imura et al.; the investigators proposed that low extracellular free calcium can induce PTH secretion through the klotho- and Na+,K+-adenosine triphosphatase (Na+,K+-ATPase)-dependent process [2].

Na+,K+-ATPase is a highly conserved integral membrane protein and is composed . . . [Full Text of this Article]



   Calcium and Na+,K+-ATPase activity
 


   Klotho and Na+,K+-ATPase activity
 


   PTH and Na+,K+-ATPase activity
 


   Conclusion
 

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