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Speaker Abstracts
Tuesday, 6 February 2007
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How common is early CKD?
How robust is eGFR as a measure for early CKD?
Department of Clinical Biochemistry, East Kent Hospitals NHS Trust, Kent and Canterbury Hospital, Canterbury, Kent, UK, CT1 3NG
Correspondence to: Email: edmund.lamb@ekht.nhs.uk
Glomerular filtration rate (GFR) is accepted as the best overall measure of kidney function but measurement using reference procedures (e.g. 51Cr-EDTA) is impractical for large-scale application. Internationally there has been a recent thrust towards earlier detection of chronic kidney disease (CKD), primarily using estimated GFR (eGFR) as a tool [1]. Quality requirement one of Part 2 of the Renal NSF was aimed at prevention and early detection of CKD and to satisfy this it was recommended that clinical biochemistry laboratories report eGFR alongside all requests received for serum creatinine measurement in adults [2]. In April 2006, the Department of Health in England recommended universal eGFR reporting using the ID-MS standardized MDRD equation [3] with appropriate adjustment for assay differences and the Quality and Outcomes Framework (QOF) introduced a register of people in primary care with stages 3–5 CKD. Clinical practice guidelines to support these
1Belfast City Hospital and 2Queen's University Belfast, Northern Ireland
Department of General Practice and Primary Care, University of Aberdeen
Ruperto-Carola University, Heidelberg, Germany
Renal Unit, Dumfries and Galloway Royal Infirmary, Dumfries, DG1 4AP
BHF Glasgow Cardiovascular Research, University of Glasgow, Glasgow G12 8TA
Renal Unit, Guy's; Hospital, London SE1 9RT
Nottingham Renal & Transplant Unit, Nottingham City Hospital, Nottingham NG5 1PB
Hope Hospital, Salford M6 8HD
Nottingham University Hospital NHS Trust
Health Economics Research Unit, University of Aberdeen
John Walls Renal Unit, Leicester General Hospital, Leicester
Sheffield Kidney Institute, Sheffield, UK