Skip Navigation


NDT Advance Access originally published online on April 9, 2007
Nephrology Dialysis Transplantation 2007 22(7):1806-1810; doi:10.1093/ndt/gfm185
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
22/7/1806    most recent
gfm185v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Singh, A. K.
Right arrow Articles by Reddan, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Singh, A. K.
Right arrow Articles by Reddan, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Anaemia of CKD—the CHOIR study revisited{dagger}

Ajay K. Singh1, Lynda Szczech2, Kezhen L. Tang3, Huiman Barnhart4, Shelly Sapp2, Marsha Wolfson3 and Donal Reddan2,5

1Renal Division, Brigham and Women's Hospital and Harvard Medical School, Boston, USA 2Renal Division, Duke University Medical Center and Duke Clinical Research Institute, Durham, USA 3Ortho Biotech Clinical Affairs, Bridgewater, NJ, USA 4Department of Biostatistics and Bioinformatics, Duke University, Durham, USA 5Department of Medicine, University College Galway, Ireland

Correspondence and offprint requests to: Dr A. K. Singh, Renal Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Email: asingh@partners.org

Keywords: anaemia; CKD; epoetin; haemoglobin; kidney disease

The first 150 words of the full text of this article appear below.



   Introduction
 
Anaemia is a common complication of kidney disease and is treated with erythropoietin. However, the optimal target haemoglobin (Hb) in treating CKD anaemia has become quite controversial. There have been several randomized controlled studies of erythropoietin among kidney patients published over the past several years. The Normal Hematocrit study (NHS), a study of high-risk dialysis patients [1], was published in 1998 and was controversial at the time, as it appeared to contradict conventional wisdom by suggesting that aggressive anaemia correction may not be beneficial to haemodialysis patients with pre-existing cardiovascular disease. More recently, two studies of pre-dialysis CKD patients, the Correction of Hemoglobin Outcomes in Renal Insufficiency (CHOIR) study [2] and the Cardiovascular Risk Reduction by Early Anemia Treatment with Epoetin Beta (CREATE) study [3], focused on patients at early stages of CKD. The publication of these two studies has again attracted much discussion . . . [Full Text of this Article]



   The CHOIR study
 


   CHOIR-related questions
 
Why were the Hb targets of 11.3 and 13.5 g/dl chosen as targets and why were these targets changed from the initial targets?
Why 10 000 units subcutaneously of epoetin-alpha as the initial dose used in the study?
Imbalance in key baseline covariates
High rate of withdrawal in CHOIR
Did the DSMB follow RCT convention with regards to stopping the study?
Quality of Life measurements in the CHOIR study
Patients who dropped out of the study did not add clinical information


   Conclusions
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
I. C. Macdougall, K.-U. Eckardt, and F. Locatelli
Latest US KDOQI Anaemia Guidelines update what are the implications for Europe?
Nephrol. Dial. Transplant., October 1, 2007; 22(10): 2738 - 2742.
[Full Text] [PDF]