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Haem oxygenase-I plays a major role in vascular pathology, atherosclerosis, hypertension, acute kidney injury, and in the chronic nephropathy as complication of sickle cell disease. The role of this enzyme system is dual: potentially beneficial as well as injurious. Further studies on the identification of the effects of HO-I induction would provide us new insights on mechanisms reducing tissue pathology. See article by Hill-Kapturczak and Agarwal, pages 1495–1498
The occurrence of extraosseous calcification and its prevention is one of the
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