NDT Advance Access originally published online on April 3, 2007
Nephrology Dialysis Transplantation 2007 22(6):1512-1517; doi:10.1093/ndt/gfm167
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
For patients taking herbal therapylessons from aristolochic acid nephropathy
Nephrology, Dialysis and Renal Transplantation, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium
Correspondence and offprint requests to: Joëlle L. Nortier, MD, PhD, Nephrology, Dialysis and Renal Transplantation, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik, 808, 1070 Brussels, Belgium. Email: jnortier@ulb.ac.be
Keywords: Aristolochia; complementary and alternative medicine; herbal remedies; toxic nephropathy
| The first 150 words of the full text of this article appear below. |
| Introduction |
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Herbal medicines are but one component of complementary and alternative medicine (CAM), which includes acupuncture, chiropractic manipulation, meditation, reflexology, homeopathy, folk medicine and other approaches [1]. The term CAM has been defined by Eisenberg and colleagues in the nineties as those interventions neither taught widely at US medical schools nor generally available in US hospitals [2]. The increasing popularity of these therapies is attested by US national surveys showing an increase of 25% in the overall prevalence of use between 1990 and 1997. The Centers for Disease Control and Prevention reported that 29% of the adults in the US used CAM in 1999, with 10% ingesting herbal medicines [1]. In 2001, 17.8 billion USD were spent on dietary supplements, and 4.2 billion USD of this were for herbs and other botanical remedies [3]. Herbal medicine is also a big business in Europe.
| Multicultural aspects of Aristolochia species |
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| Historical discovery of aristolochic acid nephropathy |
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| The wide clinical spectrum of aristolochic acid nephropathy |
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| AAN complicated by urothelial carcinoma |
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| Tubulotoxicity and carcinogenicity of Aristolochia sp. |
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| Experimental AAN |
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| Conclusion |
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