NDT Advance Access originally published online on February 13, 2007
Nephrology Dialysis Transplantation 2007 22(5):1297-1300; doi:10.1093/ndt/gfl806
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Clinical proteomics—on the long way from bench to bedside?*
1Department of Nephrology and Rheumatology, Georg-August University Goettingen, Robert-Koch-Strasse 40, D-37075 Goettingen and 2Section for Transplantation Immunology and Immunhaematology, ZMF, Eberhard-Karls University Tuebingen, Waldhoernle Str. 22, 72072 Tuebingen, Germany
Correspondence and offprint requests to: Hassan Dihazi, PhD, Department of Nephrology and Rheumatology, Georg-August University Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany. Email: dihazi@med.uni-goettingen.de
Keywords: clinical proteomics; kidney diseases; urinary proteomics
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Proteomics as diagnostic tools |
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The increasing number of patients suffering from chronic renal failure represents one of the major challenges which the nephrologists are facing worldwide. For a better therapeutic outcome of this disease, earlier detection is urgently warranted in routine clinical practice. The standard approaches in diagnosing renal diseases remain severely limited. New techniques, such as analysis of the diseased renal proteome, are highly promising [1–6]. Beside direct analysis of renal tissue, mass spectrometric approaches to urinary peptide/protein profiling promise potential value in the non-invasive diagnosis, monitoring or prediction of renal and urinary tract diseases. First examples of such progress have been reported in a recent paper of Decramer et al. [1], who report that urinary proteomic analysis can predict the need for operation in newborns presenting with unilateral uretero-pelvic junction obstruction with high significance. Furthermore, certain publications imply the possibility of an early detection of graft rejection
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What is proteomics? |
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Proteomics techniques for urine proteome analysis |
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Gel-based proteome analysis
Gel-free proteome analysis
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Urinary proteome analysis as clinical diagnostic tool |
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