NDT Advance Access originally published online on January 8, 2007
Nephrology Dialysis Transplantation 2007 22(4):999-1001; doi:10.1093/ndt/gfl797
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
In memoriam analgesic nephropathy (circa 19722006)
Acacialaan 54; Herent, B3020, Belgium
Correspondence and offprint requests to: Email: paul.michielsen@med.kuleuven.be
Keywords: analgesic nephropathy; mixed analgesics; phenacetin
| The first 150 words of the full text of this article appear below. |
Throughout the last decades, analgesic nephropathy (AN) has remained a subject for controversy, leading to a series of epidemiological studies, reviews, statements by more or less officially appointed committees and appeals to public health authorities. In contrast, the Obituary to Analgesic Nephropathy which appeared in the November issue of NDT [1] reports only a decisive new fact: 20 years after the removal of phenacetin from the freely available analgesics, the typical lesions of AN are no longer found at autopsy in Basel. How does this new evidence fit into the other available pieces of the puzzle?
It all started in the 50s, with localized epidemics of chronic renal failure in Sweden, in Swiss watch factories, in the Flanders region of Belgium and in Australia. All had in common a compulsive craving for analgesic mixtures, usually powders containing phenacetin combined with other antipyretic analgesics, caffeine and sometimes codeine. The