NDT Advance Access originally published online on August 8, 2007
Nephrology Dialysis Transplantation 2007 22(12):3674-3676; doi:10.1093/ndt/gfm514
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Rituximab induces complete remission in a case of membranous nephropathy associated with hepatitis C virus- related infection
Email: c.manno@nephro.uniba.it
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Sir,
Idiopathic membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults. Corticosteroids, cytotoxic agents and cyclosporine have been largely used in idiopathic MN, but their use may be ineffective or contraindicated in some patients [1]. The pathogenetic potential of B cells in this disease has been employed to explore the therapeutic use of new drugs, such as rituximab, a monoclonal antibody to B-cell antigen CD20. CD20 expression is limited to B cells, begins in humans at the early pre-B-cell stage, and persists until the B cells undergo terminal plasma cell differentiation. The binding of rituximab to the surface receptor of B cells inhibits their activation, proliferation, differentiation and
Case report
Comments
Department of Emergency and
Organ Transplantation,
Renal, Dialysis and
Transplant Unit,
University of Bari,
Bari,
Italy
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A. S. Bomback, V. K. Derebail, J. G. McGregor, A. V. Kshirsagar, R. J. Falk, and P. H. Nachman Rituximab Therapy for Membranous Nephropathy: A Systematic Review Clin. J. Am. Soc. Nephrol., April 1, 2009; 4(4): 734 - 744. [Abstract] [Full Text] [PDF] |
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