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Nephrology Dialysis Transplantation 2007 22(12):3411-3412; doi:10.1093/ndt/gfm554
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


What goes in must come out—the small intestine modulates renal phosphate excretion*

Carsten A. Wagner, Jürg Biber and Heini Murer

Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland

Correspondence to: Carsten A. Wagner, Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. Email: wagnerca@access.unizh.ch

Keywords: intestinal absorption; kidney; phosphate; phosphatonin; proximal tubule

The first 10% of the full text of this article appears below.

In a recent article in PNAS, Berndt et al. describe a novel and rapid regulation of renal phosphate excretion by phosphate instilled into the small intestine [1]. In a series of elegant experiments, renal phosphate clearance was measured before and during the infusion of a small amount of phosphate into the distal duodenum of rats. Twenty minutes after the infusion, massive phosphaturia was observed. This effect was specific for phosphate and was not seen when phosphate was instilled into the stomach or when NaCl was applied. Phosphaturia occurred without a measurable increase in serum phosphate and . . . [Full Text of this Article]


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