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Nephrology Dialysis Transplantation 2007 22(10):2738-2742; doi:10.1093/ndt/gfm562
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


Latest US KDOQI Anaemia Guidelines update—what are the implications for Europe?

Iain C. Macdougall1, Kai-Uwe Eckardt2 and Francesco Locatelli3

1Department of Renal Medicine, King's College Hospital, London, UK, 2Department of Nephrology and Hypertension, University of Erlangen-Nuremberg, Germany and 3Department of Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy

Correspondence to: Dr Iain C Macdougall, Consultant Nephrologist, Renal Unit, King's College Hospital, London SE5 9RS. Email: Iain.macdougall@kch.nhs.uk

Keywords: anaemia; clinical guidelines; EBPG; KDIGO; KDOQI; CREATE; CHOIR; TREAT

The first 150 words of the full text of this article appear below.

In medicine, large randomized controlled trials are powerful entities; not only do they influence clinical practice and impact on clinical practice guidelines, but they also have the ability to confuse the medical and non-medical community by producing surprising or alarming results that question current concepts of clinical management. Examples of this in the non-nephrological literature include the Women's Health Initiative trial of hormone replacement therapy for cardiovascular protection in post-menopausal women [1]. This very large placebo-controlled randomized trial in over 16 000 post-menopausal women showed beyond doubt that combined oestrogen and progesterone replacement did not reduce cardiovascular risk, but in fact increased it. Similarly, in the CAST trial (Cardiac Arrhythmia Suppression Trial), the hypothesis was that anti-arrhythmic drugs such as flecainide and encainide would reduce the incidence of ventricular arrhythmias post-myocardial infarction [2]. In fact, mortality was increased with the use of such agents. Closer to . . . [Full Text of this Article]


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