NDT Advance Access originally published online on October 13, 2006
Nephrology Dialysis Transplantation 2007 22(1):9-11; doi:10.1093/ndt/gfl580
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Which cardiovascular risk factors matter in chronic kidney disease?
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Oxford, UK
Correspondence and offprint requests to: Prof Colin Baigent, Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK. Email: colin.baigent@ctsu.ox.ac.uk
Keywords: blood pressure; cholesterol; epidemiology; haematocrit; randomized trials; risk factors
| The first 10% of the full text of this article appears below. |
| Why measure risk factors for vascular disease? |
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Identifying cardiovascular risk factors among patients with chronic kidney disease (CKD) is potentially useful for two main reasons. First, such risk factors may be used to predict the future risk of an event, which may help physicians to plan treatment. Second, they may be targets for intervention to prevent such events. It is now clear that a large number of risk factors independently predict the risk of cardiovascular outcomes among dialysis patients [1] and among patients with lesser degrees of renal impairment [2]. But, although a risk score based on independent risk factors can be assembled without particular regard to whether they are causal, treatments which modify a particular risk factor will only be effective for the prevention of vascular disease if that risk factor is a cause of such disease.
| Limitations of dialysis studies for identifying causes of vascular disease |
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The starting point for identifying risk factors that might prove to be
| Alternative strategies for identifying causes of vascular disease in CKD |
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| Average levels of risk factors may to be too high for CKD patients |
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| Assessing risk factors which are specific to CKD |
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| Summary |
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