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NDT Advance Access originally published online on September 2, 2006
Nephrology Dialysis Transplantation 2007 22(1):37-39; doi:10.1093/ndt/gfl485
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Dynamics at the slit diaphragm—is nephrin actin'?*

Marcus J. Moeller

RWTH Aachen, Division of Nephrology, Internal Medicine 2, Pauwelsstr. 30, 52074 Aachen, Germany

Correspondence and offprint requests to: Marcus Johannes Moeller, MD, RWTH Aachen, Division of Nephrology, Internal Medicine 2, Pauwelsstr. 30, 52074 Aachen, Germany. Email: mmoeller@ukaachen.de

Keywords: actin; FAT1; foot process; Nck; nephrin; podocyte

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Two manuscripts published by Verma et al. in the Journal of Clinical Investigation and by Jones et al. in Nature show that nephrin interacts with the actin polymerization complex via the adaptor protein Nck at the slit diaphragm.

The glomerular filter has remained one of the most intriguing mysteries in the field of nephrology. How is it possible that the kidney filters millions of litres of fluid from the plasma in a lifetime and never clogs? How can plasma proteins be so efficiently retained within the serum by this nano-structure? And why does a glomerulus become proteinuric in diseased states?

The glomerular filter is composed of three major components: the fenestrated endothelial cells, the glomerular basement membrane and the podocytes, which form multiple interdigitating foot processes. Podocytes form an unusual intercellular junction, termed . . . [Full Text of this Article]


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