NDT Advance Access originally published online on October 18, 2006
Nephrology Dialysis Transplantation 2007 22(1):15-20; doi:10.1093/ndt/gfl581
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Metabolic syndrome: a fata morgana?
1Department of Internal Medicine and 2Department of Clinical Pharmacology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
Correspondence and offprint requests to: Dr S. J. L. Bakker, Department of Internal Medicine, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands. Email: s.j.l.bakker@int.umcg.nl
Keywords: cardiovascular disease; dialysis; endstage renal disease; metabolic syndrome; obesity; renal insufficiency
| The first 150 words of the full text of this article appear below. |
| Metabolic syndrome: metabolic/medical complications of obesity |
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The criteria used to define the metabolic syndrome are increased waist circumference, increased triglycerides, decreased HDL-cholesterol, increased blood pressure and increased plasma glucose. According to the most widely used definition, the metabolic syndrome is diagnosed in persons who have three or more of these five abnormalities [1]. The history of the designation of the syndrome dates back to 1993, when it was stressed in the second report of the Adult Treatment Panel (ATP-II) of the National Cholesterol Education Program (NCEP), that the rising prevalence of obesity should be controlled from the perspective of prevention of cardiovascular (CV) disease [2]. Later, it was acknowledged that, despite recommendations, the problem of obesity had taken immense proportions, and that it would be a daunting task to treat every obese subject. In the third report of the Adult Treatment Panel (ATP-III) of the NCEP, in 2001, the metabolic syndrome was
| Is the metabolic syndrome useful for assessment of cardiovascular or renal risk? |
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| Is the concept of the metabolic syndrome then worthless? |
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| What warnings does the obesity epidemic contain for kidneys and dialysis capacity? |
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| Medical complications of prolonged obesity |
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| Obesity-related renal disease |
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| Potential impact of an obesity paradox on incidence of ESRD |
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| Implications of the metabolic syndrome for the management of renal patients |
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Ar. Mani, J. Radhakrishnan, H. Wang, Al. Mani, M.A. Mani, C. Nelson-Williams, K.S. Carew, S. Mane, H. Najmabadi, D. Wu, et al. Metabolic Syndrome--What We Know and What We Don't Know: LPR6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors. Science 315: 1278-1282, 2007 J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1619 - 1623. [Full Text] [PDF] |
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