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NDT Advance Access originally published online on May 15, 2006
Nephrology Dialysis Transplantation 2006 21(8):2072-2074; doi:10.1093/ndt/gfl206
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Translational Nephrology

Haematopoietic stem cells—role of calcium-sensing receptor in bone marrow homing*

Tilman Bernhard Drüeke

Inserm Unit 507 and Service de Néphrologie, Hôpital Necker, Paris, France

Correspondence and offprint requests to: Tilman B. Drüeke, MD, FRCP, Unité 507 de l'Inserm and Service de Néphrologie, Hôpital Necker, 161 rue de Sèvres, 75743 Paris Cedex 15, France. Email: drueke@necker.fr

Keywords: bone; calcium-sensing receptor; erythropoiesis; haematopoiesis; liver; stem cells

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Erythropoiesis switches from liver to bone around the time of birth [1], hepatic erythropoietin production is progressively replaced by renal erythropoietin production [2] and fetal haemoglobin gives way to adult haemoglobin [3]. The mechanisms involved in these translocations and changes remain largely a mystery. After birth, the haematopoietic stem cells (HSCs) migrate via the circulation to specific sites in the bone marrow (Figure 1). These are cavities at the endosteal surface of the bone called ‘stem cell niche’ [4,5]. Notably, transplanted HSCs lodge at the endosteal niche within hours of intravenous injection [6].


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  		Fig. 1. Schematic view of the neonatal switch of haematopoiesis from liver to bone and the role of the CaR. Normal CaR expression . . . [Full Text of this Article]

 

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