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NDT Advance Access originally published online on April 20, 2006
Nephrology Dialysis Transplantation 2006 21(7):1770-1772; doi:10.1093/ndt/gfl178
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Translational Nephrology

Klotho, an important new factor for the activity of Ca2+ channels, connecting calcium homeostasis, ageing and uraemia

Comments on Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoenderop JG. The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 2005; 310:490–493

Ewa Lewin and Klaus Olgaard

Nephrological Departments B & P, Herlev Hospital & Rigshospitalet, Copenhagen, Denmark

Correspondence and offprint request to: Klaus Olgaard, Nephrological Departments P, Rigshospitalet, Copenhagen, Denmark. Email: olgaard@rh.dk

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In human ageing, changes in calcium distribution take place. The calcium content in bone tissue diminishes and extraskeletal calcifications, especially vascular calcifications, occur. Recent research has documented the fact that the vascular calcification process is regulated [1,2] and that this process is accelerated in uraemia [3]. Multiple factors have been proposed to influence the process of ageing. An interrelationship between sex hormones and calcium homeostasis is well established [4]. In the last decade, a new hormone, klotho, has emerged as an important player in the ageing process [5,6], and a connection between klotho and the . . . [Full Text of this Article]


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 Nephrol Dial TransplantHome page
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Klotho spins the thread of life--what does Klotho do to the receptors of fibroblast growth factor-23 (FGF23)?
Nephrol. Dial. Transplant., June 1, 2007; 22(6): 1524 - 1526.
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