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NDT Advance Access originally published online on January 9, 2006
Nephrology Dialysis Transplantation 2006 21(5):1157-1161; doi:10.1093/ndt/gfk037
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Editorial Comment

What you should know about the work-up of a renal biopsy

Kerstin Amann1 and Christian S. Haas2

Departments of 1 Pathology and 2 Internal Medicine IV, University of Erlangen-Nürnberg, Germany

Correspondence and offprint requests to: Professor Dr med. Kerstin Amann, Department of Pathology, University of Erlangen-Nürnberg, Krankenhausstr. 8–10, D-91054 Erlangen, Germany. Email: kerstin.amann@patho.imed.uni-erlangen.de

Keywords: renal biopsy; workup; morphology; immunohistology; immunofluorescence; electron microscopy

The first 150 words of the full text of this article appear below.

To obtain relevant clinical information from a renal biopsy is an interdisciplinary task, requiring close cooperation between clinician and pathologist. The better the nephrologist's understanding, the more rewarding the information from the pathologist. Based on our experience, we will discuss some practical points which are not often known or are poorly handled by our clinical partners.

Since these points require close interaction between clinicians and pathologists, some guidelines concerning the procedure and work-up of routine kidney biopsy have been established by the Renal Pathology Society [1].

Standard procedures for renal biopsy handling and processing were established at the European Union Consensus Meeting, which took place on February 25, 2000 in Vienna, Austria; these procedures cover the following aspects [1]:

  • Taking the biopsy
  • Transferring the material
  • Dividing the sample
  • Preserving the tissue
  • Cutting the biopsy sample
  • Staining the biopsy sample
  • Reporting the finding
  • Establishing the diagnosis

If . . . [Full Text of this Article]



   What size of the biopsy is minimal and optimal for the pathologist?
 


   What clinical information is indispensable to the pathologist?
 


   How should a renal biopsy be handled?
 


   What you should know about how the pathologist works-up the renal biopsy
 
Light microscopy (Figure 1A–D)


   What are immunohistochemistry and immunofluorescence, and what information can be obtained from them?
 


   When is electron microscopy necessary?
 


   What information is provided by electron microscopy?
 


   How should the pathologist report the findings in a renal biopsy?
 

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