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NDT Advance Access originally published online on February 7, 2006
Nephrology Dialysis Transplantation 2006 21(4):850-853; doi:10.1093/ndt/gfl019
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Editorial Comment

Inflammation and hypertension: the search for a link

Paolo Pauletto and Marcello Rattazzi

Dipartimento di Medicina Clinica e Sperimentale, Università di Padova, Italy

Correspondence and offprint requests to: Prof. Paolo Pauletto, Dipartimento di Medicina Clinica e Sperimentale Università di Padova and Medicina Interna I, Ospedale Ca’Foncello, Via Ospedale, 31100 Treviso, Italy. Email: ppauletto@ulss.tv.it

Keywords: atherosclerosis; arterial stiffness; cytokines; hypertension; inflammation; smooth muscle cells

The first 150 words of the full text of this article appear below.



   Introduction
 
The last decade has shown an increase in the relevance of inflammation and its mediators in vascular biology; thus, the role of inflammation during atherogenesis is now a matter of intense investigation [1,2]. Basic science studies proved that elements belonging to both innate and adaptive immunity can be involved in the formation, progression and complication of atherosclerosis [2]. Plasma levels of circulating inflammatory molecules, such as C-reactive protein (CRP) and interleukin-6 (IL-6), have been shown to be predictive of future cardiovascular disease (CVD), and drugs which modify their levels can reduce the risk of myocardial infarction and stroke [3]. It has been known for years that hypertension represents an important risk factor for CVD and its treatment is mandatory to prevent future adverse events. To date, however, very little data are available concerning a potential link between inflammation and hypertension. Inflammation and . . . [Full Text of this Article]



   Epidemiological evidence
 


   Potential pathophysiological connection
 


   Conclusions
 

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