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Nephrology Dialysis Transplantation 2006 21(4):837-838; doi:10.1093/ndt/gfl058
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Editorial Comment

MRSA: total war or tolerance?

Dirk Vogelaers

Department of Infectious Diseases, University Hospital Gent, Belgium

Correspondence and offprint requests to: Dirk Vogelaers, Department of Infectious Diseases, University Hospital Gent, Belgium. Email: dirk.vogelaers@ugent.be

Keywords: MRSA infection; ICU's; preventive infection

The first 10% of the full text of this article appears below.

Both methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) can cause potentially severe infections, such as bacteraemia, surgical site infections, complicated skin and soft tissue infections (SSTI), and ventilator-associated pneumonia. However, they are also involved in a large number of mainly minor SSTI and are often mere colonizers without leading to clinical infections. Severe MRSA infections are associated with increased length of stay, morbidity, cost (primarily driven by increased length of stay and not by the cost of antimicrobials) and mortality. In a large meta-analysis of 31 studies of S. aureus bacteraemia pooled between 1980 and 2000 [1], Cosgrove et al. [1] found a doubling of mortality with MRSA bacteraemia (OR 1.93; 95% confidence interval (CI) 1.54–2.42; P<0.001 vs MSSA). In another calculation, MRSA bacteraemia . . . [Full Text of this Article]


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