NDT Advance Access originally published online on December 22, 2005
Nephrology Dialysis Transplantation 2006 21(3):568-573; doi:10.1093/ndt/gfk010
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Editorial Comment
Bone morphogenic protein-7 and the kidney: current concepts and open questions
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Correspondence and offprint requests to: Dr Michael Zeisberg, Center for Matrix Biology, Beth Israel Deaconess Medical Centre, Harvard Medical School, 330 Brookline Avenue, RW511, Boston, MA 02215. Email: mzeisber@bidmc.harvard.edu
Keywords: Bone Morphogenic Protein-7 (BMP-7); Fibrosis; Epithelial Mesenchymal Transition (EMT); Chronic Kidney Disease (CKD); Chronic Renal Failure (CRF)
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
Several recent studies have demonstrated unequivocally that administration of bone morphogenic protein-7 (BMP-7) has a therapeutic effect in various animal models of acute and chronic renal injury (Table 1). However, the underlying mechanisms of BMP-7 action in the kidney remained largely unknown in these initial reports. Here, novel aspects regarding the biology of BMP-7 in the kidney will be discussed.
|
|
What is BMP-7? |
|---|
BMP-7, also known as Osteogenic protein-1 (OP-1), is one of 15 currently known BMPs, which are structurally and functionally related and which are part of the transforming growth factor ß (TGF-ß) superfamily of growth factors [1]. BMP-7 was originally identified as a regulator of cartilage and bone formation [2]. However, BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types,
|
What is the role of BMP-7 in the developing kidney? |
|---|
|
How does BMP-7 protect the kidney from injury? |
|---|
|
How is the biological activity of endogenous BMP-7 in the kidney regulated? |
|---|
|
Is there a role for kidney derived BMP-7 outside the kidney? |
|---|
|
How can these insights into the biology of BMP-7 impact on clinical nephrology? |
|---|
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M.-A Yu, K.-S. Shin, J. H. Kim, Y.-I. Kim, S. S. Chung, S.-H. Park, Y.-L. Kim, and D.-H. Kang HGF and BMP-7 Ameliorate High Glucose-Induced Epithelial-to-Mesenchymal Transition of Peritoneal Mesothelium J. Am. Soc. Nephrol., March 1, 2009; 20(3): 567 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Q. Nguyen, P. Roestenberg, F. A. van Nieuwenhoven, N. Bovenschen, Z. Li, L. Xu, N. Oliver, J. Aten, J. A. Joles, C. Vial, et al. CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy J. Am. Soc. Nephrol., November 1, 2008; 19(11): 2098 - 2107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Boor, K. Sebekova, T. Ostendorf, and J. Floege Treatment targets in renal fibrosis Nephrol. Dial. Transplant., December 1, 2007; 22(12): 3391 - 3407. [Full Text] [PDF]
|
|
|
|
|
|
S. Mezzano, A. Droguett, M. Eugenia Burgos, C. Aros, L. Ardiles, C. Flores, D. Carpio, G. Carvajal, M. Ruiz-Ortega, and J. Egido Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis Nephrol. Dial. Transplant., July 1, 2007; 22(7): 1882 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sugimoto, G. Grahovac, M. Zeisberg, and R. Kalluri Renal Fibrosis and Glomerulosclerosis in a New Mouse Model of Diabetic Nephropathy and Its Regression by Bone Morphogenic Protein-7 and Advanced Glycation End Product Inhibitors Diabetes, July 1, 2007; 56(7): 1825 - 1833. [Abstract] [Full Text] [PDF]
|
|