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NDT Advance Access originally published online on November 25, 2005
Nephrology Dialysis Transplantation 2006 21(2):264-267; doi:10.1093/ndt/gfi290
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Editorial Comment

Obesity and hypertension—the issue is more complex than we thought

Krzysztof Narkiewicz

Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland

Correspondence and offprint requests to: Krzysztof Narkiewicz, MD, PhD, Department of Hypertension and Diabetology, Medical University of Gdansk, Debinki 7c, 80-952 Gdansk, Poland. Email: knark@amg.gda.pl

Keywords: cardiovascular disease; chronic kidney disease; hypertension; obesity

The first 150 words of the full text of this article appear below.

‘That which does not kill you, makes you stronger’—Friedrich Nietzsche



   Introduction
 
The relevance of both hypertension and obesity, as important public health challenges, is increasing worldwide. Compared with the year 2000, the number of adults with hypertension is predicted to increase by ~60% to a total of 1.56 billion by the year 2025 [1]. The growing prevalence of obesity is increasingly recognized as one of the most important risk factors for the development of hypertension. This epidemic of obesity and obesity-related hypertension is paralleled by an alarming increase in the incidence of diabetes mellitus and chronic kidney disease.

This editorial examines the evidence linking obesity with hypertension, reviews the mechanisms underlying this link, and discusses its potential implications for renal disease. Earlier studies attributed the link between obesity and hypertension primarily to haemodynamic factors. Recent evidence indicates that the association is much more complex than initially thought.



   Good weight and measure are heaven's treasure
 
Excess body . . . [Full Text of this Article]



   Still waters run deep
 


   It takes two to tango
 


   A chain is not stronger than its weakest link
 


   Think globally, act globally
 


   Every rule has its exception
 


   Conclusions
 

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