NDT Advance Access originally published online on December 2, 2005
Nephrology Dialysis Transplantation 2006 21(2):260-263; doi:10.1093/ndt/gfi319
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Editorial Comment
Role of inflammatory cells in the kidney in the induction and maintenance of hypertension
1 Hospital Universitario and Universidad del Zulia, Instituto de Investigaciones Biomédicas, Maracaibo, Venezuela and 2 Renal Department, University of Florida, USA
Correspondence and offprint requests to: Bernardo Rodriguez-Iturbe, Renal Service, 9° Piso, Hospital Universitario, Avenida Goajira s/n, Maracaibo, Venezuela. Email: bri@iamnet.com
Keywords: hypertension; inflammation
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‘Two forms of inflammation can be separated from one another; the purely parenchymatous inflammation, where the process runs its course in the interior of the tissue ... and the secretory (exudative) inflammation where an increased escape of fluid takes place from the blood ... Every parenchymatous inflammation has from its outset a tendency to alter the histological and functional character of an organ’. Rudolf Virchow (1860).
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Introduction |
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The incidence of hypertension has increased dramatically in the last decade [1]. While the relative importance of environmental, congenital and genetic factors have been extensively debated, there is a general agreement that, whatever the cause, there is a dysfunction in the mechanisms responsible for sodium excretion by the kidney [2]. Not surprisingly, a reduction in dietary sodium is one of the time-honoured mainstays of all antihypertensive regimes.
Recent attention has been focused in the renal accumulation of inflammatory
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Inflammatory cells in the kidney in human and experimental hypertension |
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Sodium retention as an expected result of intrarenal inflammation |
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General overview of the pathogenesis of hypertension in relation to intrarenal inflammation |
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Sustained interstitial inflammation and the maintenance of hypertension |
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Questions for the future |
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