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NDT Advance Access originally published online on November 1, 2005
Nephrology Dialysis Transplantation 2006 21(2):251-254; doi:10.1093/ndt/gfi227
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Editorial Comment

Is it practical to screen dialysis patients for vascular calcification?

Christopher W. McIntyre

Department of Renal Medicine, Derby Hospitals Foundation NHS Trust and Centre for Integrated Systems in Biology and Medicine, University of Nottingham, UK

Correspondence and offprint requests to: Christopher W. McIntyre, Derby City General Hospital, Uttoxeter Road, Derby DE22 3NE, UK. Email: Chris.McIntyre@derbyhositals.nhs.uk

Keywords: calcification; screening; EBCT

The first 150 words of the full text of this article appear below.



   Introduction
 
Vascular calcification is becoming increasingly appreciated as an important risk factor for cardiovascular morbidity and mortality in chronic kidney disease (CKD) patients who are receiving dialysis therapy. Calcification of coronary arteries and peripheral conduit arterial vasculature is highly prevalent [1] in both haemodialysis (HD) and peritoneal dialysis (PD) patients, although most studies up to now have focused on HD [2,3]. These structural changes are associated with significant functional disturbance, chiefly resulting in reduced arterial compliance [4]. Reduction in arterial compliance increases the pulse wave velocity and predisposes to demand myocardial ischaemia [5], especially when combined with the characteristic ‘phenotype’ of the chronic dialysis patient, which includes a high incidence of epicardial coronary artery disease, small vessel myocardial disease and increased left ventricular mass, all predisposing to myocardial ischaemia. Moreover, vascular calcification with associated reduced arterial compliance is associated with reduced . . . [Full Text of this Article]



   Ultrasound based methods
 


   Plain radiology
 


   Electron beam computed tomography (EBCT)
 


   Other computed tomography (CT) techniques
 


   Conclusion
 

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