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NDT Advance Access originally published online on August 3, 2006
Nephrology Dialysis Transplantation 2006 21(12):3368-3370; doi:10.1093/ndt/gfl199
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Renal fibrosis and the origin of the renal fibroblast

Frank Strutz and Gerhard A. Müller

Department of Nephrology and Rheumatology, Georg-August-University Medical Center, Göttingen, Germany

Correspondence and offprint requests to: Frank Strutz, MD, Department of Nephrology and Rheumatology, Georg-August-University Medical Center, Robert-Koch-Str. 40, 37099 Goettingen. Email: fstrutz@gwdg.de

Keywords: cortical fibroblast; epithelial mesenchymal transition; fibrosis; progression

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Many studies have determined that the extent of tubulointerstitial involvement, particularly fibrosis, correlates better with renal function than glomerular changes do, thus, the extent of tubulointerstitial damage in any given renal biopsy has important implications for the renal prognosis of the patient (summarized in [1]). Tubulointerstitial fibrosis is characterized by the accumulation of extracellular matrix components including collagen types I, III, IV, proteoglycans and fibronectin. In recent years, much controversy has been created in the nephrology community regarding the origin of matrix-producing cells in the kidney. Several possibilities exist, including activation of resident interstitial fibroblasts, migrating haematopoietic or mesenchymal stem cells from the bone marrow, periadventitial cells and epithelial–mesenchymal transition (EMT) of tubular epithelial cells. This review summarizes recent data indicating the possible origin of matrix-producing cells in the kidney, and illustrates from a clinical point of . . . [Full Text of this Article]



   Myofibroblasts and non-myofibroblasts
 


   Is the origin of the renal fibroblast comparable in different forms of progressive renal disease?
 


   Therapeutic implications
 


   Conclusion
 

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