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NDT Advance Access originally published online on September 8, 2006
Nephrology Dialysis Transplantation 2006 21(11):3046-3047; doi:10.1093/ndt/gfl226
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Uric acid and the immune response*

Michael S. Gersch and Richard J. Johnson

University of Florida, Department of Medicine, Gainesville, Florida, USA

Correspondence and offprint requests to: Michael S. Gersch, MD, University of Florida, Room CG98, 1600 SW Archer Rd, PO Box 100224, Gainesville, FL 32610-0224. Email: gerscms@medicine.ufl.edu

Keywords: caspase; inflammasome; NALP3; uric acid

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Classically, the immune system is divided into two broad categories, consisting of innate and adaptive immunity. Adaptive immunity is the specific humoral and cellular response that develops after exposure to a particular antigen. A critical aspect of adaptive immunity is the property of memory, with an enhanced response on repeat exposure to the same antigen. On the other hand, the phyllogenetically ancient innate immune system is a relatively non-specific first line of defense that does not require prior exposure to the antigen and includes . . . [Full Text of this Article]


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