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NDT Advance Access originally published online on September 8, 2006
Nephrology Dialysis Transplantation 2006 21(11):3018-3022; doi:10.1093/ndt/gfl514
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Phenotype and genotype: perspectives for peritoneal dialysis patients

Eric Goffin and Olivier Devuyst

Division of Nephrology, Université Catholique de Louvain Medical School, B-1200 Brussels, Belgium

Correspondence and offprint requests to: Olivier Devuyst, MD, PhD, Division of Nephrology, Université Catholique de Louvain, 10 Avenue Hippocrate, B-1200 Brussels, Belgium. Email: devuyst@nefr.ucl.ac.be

Keywords: genetic variants; individualized medicine; peritoneal membrane; polymorphisms; small solute transport; ultrafiltration

The first 150 words of the full text of this article appear below.



   Introduction
 
Peritoneal dialysis (PD) is currently used on ~15% of the worldwide dialysis population. Recent improvements in connectology and antibiotics management have led to a dramatic reduction in the rate and consequences of peritonitis in PD patients. Deterioration of membrane permeability, with modifications in the transport of small solutes across the peritoneal membrane (PM) and loss of ultrafiltration (UF), is the most frequent abnormality in long-term PD patients, and the main reason for technical failure. A better understanding of the mechanisms and determinants of the small solute transport and UF is now essential to achieve long-term preservation of the PM together with improvements in patient morbidity and mortality.

The transport of solutes and water across the PM occurs through three types of pores located in the capillary endothelium [1]. The ‘small pores’ (radius 40–50 Å), which correspond to the clefts located between endothelial cells, account for ~95% of the . . . [Full Text of this Article]



   Clinical importance of assessing transport properties of the peritoneum
 


   Clinical determinants of the baseline peritoneal transport
 


   Genetic determinants of the transport properties of the peritoneal membrane
 


   Conclusion
 

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