Skip Navigation


NDT Advance Access originally published online on August 18, 2006
Nephrology Dialysis Transplantation 2006 21(11):3012-3017; doi:10.1093/ndt/gfl452
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/11/3012    most recent
gfl452v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Conway, B. R.
Right arrow Articles by Peter Maxwell, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Conway, B. R.
Right arrow Articles by Peter Maxwell, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Identifying genes for diabetic nephropathy—current difficulties and future directions

Bryan R. Conway, David A. Savage and A. Peter Maxwell

Nephrology Research Group, Queen's University, Belfast, UK

Correspondence and offprint requests to: Bryan Conway, Department of Nephrology, Belfast City Hospital, Belfast BT9 7AB, UK. Email: BryanConway@ntlworld.com

Keywords: candidate gene analysis; diabetic nephropathy; genetic susceptibility; genome-wide screens; single nucleotide polymorphism

The first 150 words of the full text of this article appear below.



   Introduction
 
Diabetic nephropathy is the leading cause of end-stage renal disease in the Western world [1], placing considerable demands on health care resources and causing significant morbidity and mortality for individuals with diabetes. Improvements in glycaemic and blood pressure control, together with the introduction of inhibitors of the renin–angiotensin system, have delayed the development and progression of nephropathy [2]. However, a substantial proportion of diabetic patients still develop nephropathy despite apparently good glycaemic control [3]. This suggests that additional, as yet unidentified, pathogenic mechanisms are likely to exist and that novel alternative therapeutic strategies could significantly retard progression to nephropathy in susceptible diabetic individuals.



   Evidence for a genetic predisposition to diabetic nephropathy
 
There is growing evidence that genetic background determines the risk of nephropathy in patients with diabetes. Familial clustering of nephropathy is well-documented [4–6], and significant concordance, both for the degree of proteinuria [7] and for the severity . . . [Full Text of this Article]



   The complexity of common disease
 


   Candidate gene studies
 


   Linkage studies
 


   Recent advances
 


   Future directions
 


   Conclusion
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?