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NDT Advance Access originally published online on August 18, 2006
Nephrology Dialysis Transplantation 2006 21(11):3007-3012; doi:10.1093/ndt/gfl314
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Mechanisms of action of uroguanylin and guanylin and their role in salt handling

Aleksandra Sindic and Eberhard Schlatter

Universitätsklinikum Münster, Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Domagkstrasse 3a, 48149 Münster, Germany

Correspondence and offprint requests to: Eberhard Schlatter. Email: eberhard.schlatter@uni-muenster.de

Keywords: arachidonic acid; cGMP; G-protein; guanylate cyclase C; kidney; natriuretic peptides

The first 150 words of the full text of this article appear below.



   Introduction
 
Guanylin (GN) peptides belong to the growing family of natriuretic peptides. While atrial natriuretic peptide (ANP) is predominantly produced in the heart and causes natriuresis in the kidney [1], it was suggested that GN peptides are intestinal peptides that have effects on the kidney. GN peptides are small peptides with 15–19 amino acids. To this family belongs GN, originally isolated from rat intestine [2]. A second member of this family was isolated from opossum urine and is called uroguanylin (UGN) [3]. Two new members, renoguanylin [4] and lymphoguanylin [5], were recently discovered; however, their physiological role is still unknown.

The mechanism of the action of GN and UGN in the intestine is well-known. It is assumed that they act similarly in several other organs that express these peptides, like airways, pancreas, testis, salivary gland and sweat glands. In the kidney, . . . [Full Text of this Article]



   Endocrine function of guanylin peptides
 


   Signalling mechanisms of guanylin peptides in renal proximal tubules
 


   Signalling mechanisms of guanylin peptides in collecting ducts
 


   Involvement of guanylin peptides in renal pathology
 


   Conclusion
 

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