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NDT Advance Access originally published online on July 22, 2006
Nephrology Dialysis Transplantation 2006 21(10):2721-2723; doi:10.1093/ndt/gfl367
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Bone marrow transplantation rescues Alport mice*

Jürgen Floege1,, Uta Kunter1, Manfred Weber2 and Oliver Gross3

1Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen 2Medical Clinic I, Cologne General Hospital, Cologne and 3Department of Nephrology and Rheumatology, University of Göttingen, Göttingen, Germany

Correspondence and offprint requests to: Jürgen Floege, MD, Department of Nephrology and Clinical Immunology, University Hospital Aachen Pauwelsstr. 30, D-52057 Aachen, Germany. Email: juergen.floege@rwth-aachen.de

Keywords: Alport's syndrome; basement membrane; bone marrow transplantation

The first 10% of the full text of this article appears below.

In the 9 May 2006 issue of Proc Natl Acad Sci USA, Sugimoto and colleagues [1] described fascinating data on a potential approach to treat Alport's syndrome, a rare genetic disease leading to renal failure, which so far could not be cured. The work was highly publicized and discussed in both scientific journals and the lay press.

Alport's syndrome derives from a mutation of either the {alpha}3, {alpha}4 or {alpha}5 chain of type IV collagen, i.e. collagen types that constitute basement membranes in the renal glomerulus, the ear and the eye. Mice . . . [Full Text of this Article]



   Clinical manifestations of Alport syndrome can be retarded by bone marrow-derived cells
 


   Bone marrow-derived (stem?) cells can contribute to glomerular healing
 


   Bone marrow-derived (stem?) cells differentiate into glomerular cells
 

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