NDT Advance Access originally published online on July 19, 2006
Nephrology Dialysis Transplantation 2006 21(10):2703-2707; doi:10.1093/ndt/gfl308
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Heterogeneity of the afferent arteriole—correlations between morphology and function
1Hungarian Academy of Sciences and Semmelweis University Nephrology Research Group, 2Faculty of Medicine, Institute of Pathophysiology, Semmelweis University, Budapest, Hungary and 3Departments of Physiology and Biophysics and Medicine, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Correspondence and offprint requests to: László Rosivall, Hungarian Academy of Sciences and Semmelweis University Nephrology Research Group, Institute of Pathophysiology, Faculty of Medicine, Semmelweis University, Budapest, Nagyvarad ter 4, H-1089 Hungary. Email: rosivall@net.sote.hu
Keywords: endothelium; glomerular filtration rate; juxtaglomerular apparatus pathology; renine–angiotensin system; VEGF
| The first 150 words of the full text of this article appear below. |
The afferent arteriole (AA) is an important structural and regulatory site of blood pressure maintenance and renal salt and water conservation. The AA is considered a typical resistance vessel with ring-like smooth muscle cells in its wall, covered by a homogenous endothelial layer. It also contains renin granular cells mainly at its distal, juxtaglomerular end [1]. These cells become myosin-negative, round-shaped cells producing a large number of renin granules in their cytoplasm [2]. The AA is part of a functional syncytium at the vascular pole of renal corpuscle, called the juxtaglomerular apparatus (JGA), which consists of the afferent and efferent arterioles, the macula densa (MD) cells of the thick ascending limb and the extraglomerular mesangium [1]. Two major regulatory processes have been traditionally attributed to the AA-JGA: the control of vascular resistance and renin release. Both direct mechanisms (myogenic, neurohumoral) and indirect mechanisms (tubuloglomerular
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Historical background |
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The juxtaglomerular portion of AA is involved in TGF and renin secretion |
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Heterogeneity of the AA |
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Regulation of fenestration |
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Summary |
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